Acai Berry Extract

• Supports antioxidant function, reduces blood pressure, supports kidney health, supports blood sugar regulation, supports cardiovascular health, and may combat against cancer (273,274,275).
• Supports antioxidant function via polyphenolic components with high levels of anthocyanins (cyanidin-3-glucoside and cyanidin-3-rutinoside) (273, 274, 275).
• May combat carcinogenesis via reduction of tumor cell proliferation, multiplicity and size of the tumors, increased anti-inflammatory capacity, increased antiproliferative activity, and increased pro-apoptotic activity (273).

African Mango

• Supports appetite regulation (7).
• Reduces leptin hormone and supports improved blood glucose levels (7).
• Supports reduction of total cholesterol, body fat, and plasma glucose (blood sugar) (7).
• Supports healthy inflammatory response by reducing c-reactive protein (inflammation levels) in the body (7).

Aloe Ferox Powder

• Supports digestive, cardiovascular, and metabolic health (270).
• Supports reduction in total and low-density lipoprotein cholesterol (LDL-C) levels, glucose, and H1AC (270).
• Supports cardiovascular health via reduced levels of fasting blood glucose, HbA1c, triglycerides, total cholesterol, LDL cholesterol, and increased HDL cholesterol (271).
• Increases glucose absorption via high molecular weight enhancing glucose transport (271).
• Reduces serum concentrations of cholesterol via reducing the absorption of cholesterol from the gut.

Alpha Lipoic Acid

• Supports immune health, cardiovascular health, blood sugar regulation, reduced body fat, and improved cognitive function (158).
• Supports blood sugar regulation via increased glucose uptake in insulin-sensitive and insulin-resistant muscle (158).
• Supports cardiovascular health via increased nitric oxide production and decreased glycation of red blood cells (decreased HA1C) (158).
• Supports cognitive function via enhanced memory, focus, and reduction of neurodegenerative disease (158).
• Supports immune health via increased free radical scavenging capabilities and increased glutathione (master antioxidant) levels (158).
• Reduces body weight via decreased appetite in individuals with metabolic syndrome (158).

Beta-Alanine

• Improves exercise performance, increases nutrient delivery to exercising muscle, and reduces lactate associated neurological exercise fatigue (15).
• Reduces carnosine (muscle acidity) levels and acts as an intramuscular pH buffer (15).
• Reduces lactate “burn” associated fatigue during extreme exercise (15).

Bilberry Fruit Extract

• Supports vision health, cardiovascular function, increased nitric oxide production, blood sugar regulation, and antioxidant support (167, 168).

Biotin

• Supports conversion of food into cellular energy, hair health, skin health, and cognitive function (213, 214).
• Enhances glucose breakdown into skeletal muscle issue (213, 214).

Black Currant

• Supports immune function via high levels of polyphenols and reduction of inflammation (169).
• Supports cardiovascular health via reductions in LDL Cholesterol (169).

Black Walnut Hulls

• Supports healthy detoxification.

Caffeine

• Optimizes energy, cognitive function, and mental alertness (24).
• Supplementation with caffeine has been shown to acutely enhance exercise performance (24).

Calcium Carbonate

• Supports bone health, muscle function, and cardiovascular health (36, 37).
• Regulates processes of bone resorption, mineralization, and fracture repair (36, 37).
• Increases the effect of physical exercise on bone mineral acquisition in the period preceding puberty (36, 37).
• Prevents the development of preeclampsia (36, 37).

Capsicum

• Supports immune health.

Chlorella Powder

• Supports antioxidant function, healthy detoxification, improved energy, cardiovascular health, and combats depression (265, 266).
• Supports antioxidant function via high levels of carotenoids that product against DNA damage and scavenge free radicals (265).
• Supports cardiovascular health via reduced cholesterol and triglyceride levels (265).
• Supports detoxification via removal of methylmercury from the body (265).
• Combats depression via reduced oxidative stress in the brain (266).

Chromium

• Supports insulin function, reduced cholesterol, improved blood sugar regulation and may lower cholesterol (218, 219).

Cinnamon Bark Extract

• Supports blood sugar regulation and cardiovascular health (166).
• Decreases levels of fasting plasma glucose, total cholesterol, LDL-C, triglyceride levels, and an increase in HDL-C levels (166).
• Supports blood sugar regulation by improving insulin sensitivity and enhanced glucose uptake (166).

Copper

• Supports healthy blood sugar levels, energy metabolism and cholesterol management (143, 144).

Cranberry Extract

• Supports cardiovascular health, immune health, and may combat against urinary tract infections (156, 157).

ECGC

• An adaptogenic herb that supports antioxidant function, cognitive function, increased muscle mass, combats inflammation, stabilizes blood pressure, enhances sexual health, and enhances endurance performance (136).
• Combats inflammation via inhibition of hydroxyl radical(inflammation) and lipid peroxidation (136).
• Supports endurance performance by enhancing mitochondrial energy output during exercise (136).
• Supports increased nitric oxide production, reduces blood pressure, reduces DNA damage, increases collagen production, increases bone strength, and aids as a neuroprotective agent (31).
• Supports antioxidant function via modulation of antioxidant enzyme expression, protection against oxidative damage, and reduced reactive oxygen species (31).
• Supports cardiovascular health via reduced atherosclerosis, inhibiting lipid peroxidation, and improved endothelial vascular function (31).

Echinacea

• Increases antiviral, anti-microbial, antioxidant capacity, and supports a strong immune system (159, 160).
• Supports immune health via decreased impro-inflammatory markers (cytokines IL-6,, IL-8, and TNF) (159, 160).
• Supports adaptive and innate immunity via increased monocytes, neutrophil, natural killer cells, and CD8 T cells (159, 160).

Eleuthro

• May support increased energy and reduced stress hormones.

Garcinia Cambogia

• May support reduced fat loss, increased metabolic rate, and increased caloric expenditure from exercise. 

Garlic

• Supports cardiovascular health, immune health, joint health, reduced inflammation, gut health, and enhanced antibacterial activity (161).
• Supports cardiovascular health via reduced hypertension, reduced total cholesterol, reduced arterial stiffness (hardening of arteries), and markers of atherosclerosis (161).
• Supports joint health via reduced NF-kB activation (inflammation) in human fibroblasts cells and reduced prevalence of pain in individuals with rheumatoid arthritis (162).
• Supports gut health via increased prebiotic properties , increased microbiome population, and increased Lactobacillus and Clostridia species (163).
• Supports immune health via a reduction in inflammatory markers (CRP, TNF, IL-6) (164).

Ginger Root

• Supports immune health, reduced blood pressure, digestive health, blood sugar regulation, and sexual health in men (110).
• Supports immune health via enhanced antioxidant, antimicrobial, and anti-inflammatory properties (110).
• Supports sex hormone health via decreased oxidative stress, increased luteinizing hormone (LH) production, reduced oxidative stress, reduced lipid peroxidation, enhanced activity antioxidant enzymes, increased blood flow, and recycling of testosterone receptors (110).

Ginseng

• An adaptogenic herb that supports antioxidant function, cognitive function, increased muscle mass, combats inflammation, stabilizes blood pressure, enhances sexual health, and enhances endurance performance (136).
• Combats inflammation via inhibition of hydroxyl radical(inflammation) and lipid peroxidation (136).
• Supports endurance performance by enhancing mitochondrial energy output during exercise (136).

Goldenseal Root

• Supports digestive health, antibacterial activity, and antioxidant support (201, 202).
• Supports antioxidant function via levels of berberine (alkaloid) (201, 202).

Grapefruit

• Supports immune health via increased oxidant, free radical scavenging, and fueling neutrophilic (immune cell) activity in chemotaxis, phagocytosis, and microbial killing (97,98).
• Supports fat burning by increasing carnitine biosynthesis (molecule required for mitochondrial fatty acid oxidation) (97,98).
• Supports accelerate bone healing after a fracture, increase type I collagen synthesis, and reduce oxidative stress (inflammation) (98).
• Supports cardiovascular health via reduced atherosclerosis, inhibiting lipid peroxidation, and improved endothelial vascular function (31).

Grape Seed Extract

• Supports increased nitric oxide production, reduces blood pressure, reduces DNA damage, increases collagen production, increases bone strength, and aids as a neuroprotective agent (31).
• Supports antioxidant function via modulation of antioxidant enzyme expression, protection against oxidative damage, and reduced reactive oxygen species (31).
• Supports cardiovascular health via reduced atherosclerosis, inhibiting lipid peroxidation, and improved endothelial vascular function (31).

Green Tea Extract

• A potent polyphenolic antioxidant that supports blood pressure, insulin sensitivity, and metabolic health (26).
• High in ECGC (epigallacatechin gallate) (26).
• ECGC is shown to reduce body fat mass, increase fat oxidation (burning) and increase caloric expenditure during exercise (25).
• Potent anti-inflammatory compound supporting glutathione production and inhibition of pro-inflammatory markers (cytokines) (26).
• Reduces oxidative stress (chronic inflammation in the body) (26).

Guarana

• Supports increased energy, reduced body fat, and blood sugar regulation (346).
• Supports reduced body fat via increased mitochondrial biogenesis (creation of new fat burning machinery), and increased activation of fat burning pathway (AMPK Activation) (346).
• Supports blood sugar regulation via improved insulin sensitivity and pancreatic beta cell production of insulin (346).

Hawthorn Berries

• Supports cardiovascular health and combats metabolic syndrome (165).
• Supports cardiovascular health via reduced atherosclerotic lesion areas, reduced cholesterol synthesis (acyl-coA-cholesterol acyltransferase enzyme), reduced very-low-density lipoproteins (VLDL), and inhibited platelet aggregation (165).

Hyssop Herb Powder

• Supports respiratory health, digestive health, healthy detoxification, and may combat respiratory viruses (272).

Inulin

• Supports digestive health, influencing lipid metabolism and regulates glucose and insulin levels (268,269).

Kola Nut

• May support increased fat burning and increased energy.

L-Arginine

• Natural vasodilator precursor to increased nitric oxide levels (1).
• Supports immune function by maturation of the T cell (immune cell) receptor zeta (TCR) (2).
• Improves exercise performance via increased stroke volume (blood flow) and increased nutrient delivery to exercising muscle. (3).
• Reduces arterial blood pressure, insulin resistance, and supports fat lipolysis (fat burning) (4).

L-Carnitine

• Improves exercise performance, increases nutrient delivery to exercising muscle, and reduces lactate associated neurological exercise fatigue (15).
• Reduces carnosine (muscle acidity) levels and acts as an intramuscular pH buffer (15).
• Reduces lactate “burn” associated fatigue during extreme exercise (15).
• Improves fat burning (oxidation) by shuttling triglycerides into the mitochondria for fat metabolism (8).
• Improves cognitive decline associated with Alzheimer’s disease by increasing l-carnitine as a fuel source for the brain (8).
• Improves fat burning(oxidation) in muscle tissue during exercise (8).
• The precursor to acetylcholine (8).
• Improves memory by increasing hippocampal volume associated with fatty acid oxidation (fat burning) (8).

L-Ornithine

• Supports cardiovascular health and exercise performance by increasing production of l-arginine (5).
• L-Ornithine supports kidney health and protein metabolism by converting ammonia (toxic by product of protein metabolism) into urea in urine (5).
• Reduces stress hormone (cortisol) and improves sex hormone profile via increase in DHEA (sex hormone precursor) (6).
• Improves perceived mood, sleep quality, and decreased subjective feelings derived from stress (5).

Lutein

• A carotenoid that supports vision health, immune health, cardiovascular health, and combats diabetic retinopathy (155, 156).
• Supports increased lutein concentration in the macula and exhibits various features such as anti-inflammatory, anti-oxidative, and blue light-filtering effects (155, 156).
• Supports visual health via increased lutein concentration in the macular layer of the retina, reduced prevalence of cataracts, and improved plasma level of lutein and retinal macular pigment level (155, 156).

Lycopene

• Supports prostate health, cardiovascular support, antioxidant, anti-inflammatory, and chemopreventive properties against cancer (191,192, 193).
• Combats inflammation via scavenging of free radicals and reduced oxidative damage of DNA. (191,192,193).
• Combats carcinogenesis via carcinogen-metabolizing enzymes, apoptosis (cancer cell death), anti-proliferation, pro-differentiation, and anti-lipid peroxidation activities. (193).
• Inhibits phosphorylation of anti-oncogenes such as p53 and Rb. It also inhibits G0/G1 and S-phase of the cell cycle (193).

Macca Root

• Supports female hormonal health via increased sex drive, improved post-menopausal symptoms, and improved sexual desire (13).
• Increases luteinizing hormone (LH) production and reduced severity of menstruation (13). 
• Increases sperm count in males via androgenic mechanisms associated with free testosterone increase (13).

Magnesium

• Supports optimal nerve function, muscle contractions, cardiovascular, bone health, and decreased anxiety (90, 91).
• Supports biological reactions such as ATP-fueled reactions and pancreatic insulin secretion (90, 91).
• Supports reduction systolic blood pressure, fasting glucose, triglycerides, and healthy HDL levels (90, 91).
• Reduces peripheral cortisol levels in the CNS and supports relaxation and decreased anxiety (90, 91).

Manganese

• Supports enzymatic antioxidant reactions, increased bone mineral density, and blood sugar regulation (148, 149).

Molybdenum

• Increases enzymatic reactions involved in sulfite metabolism and detoxification (150).

Papaya Fruit Powder

• Supports immune health and digestion.
• Supports digestive health via enzymatic support of protein digestion.

Pomegranate Extract

• Supports reduced blood pressure, increased nitric oxide production, immune health, blood sugar regulation, prostate health, gut health and aids as an antimicrobial compound (170).
• Supports prostate health via high polyphenolic antioxidant levels (three times the antioxidant activity of green tea) that protect the prostate gland from inflammation (170).
• Supports reduced blood pressure via increased nitric oxide production, increased cardiac output (blood flow), and reduced cholesterol levels (170).
• Supports digestive health via combating inflammatory bowel disease (171).
• Supports immune health via reduced inflammatory cytokines (markers of inflammation) throughout the body (171).

Psyllium Husk Powder

• Supports healthy digestion, gut microbiome, healthy bowl movements, blood sugar regulation, and natural appetite suppressant (269).
• Increases stool water significant changes in microbiota in constipated patients (269).
• Reduces constipation via reduction of the bacterial genus associated with hard stools (Christensenella) (269).

Raspberry Ketone

• Decreases anxiety, supports positive mood, supports gut brain axis, and an improved sleep cycle (259,260). 
• Decreases anxiety via increases in 5 HTP (259, 260).
• Improves circadian rhythm via increased natural melatonin production (259,260).
• Supports gut brain axis via natural increased production of serotonin in gut neurons (260).
• A natural aromatic compound derived from raspberries enhancing fat oxidation(burning) and antioxidant protective mechanisms (20).
• Supports suppression of lipid accumulation (fat build up) in adipocytes (fat cells) (21).
• Increases total antioxidant capacity by increasing enzymes associated with decreasing reactive oxygen species (superoxide dismutase) (22).
• Increases natural production of master antioxidant L-Glutathione (22).

Red Clover Extract

• Supports menopausal health via reductions in hot flashes, increased estrogen production, antioxidant support, improved lipid panels, increased bone mineral density, and improved mood (152, 153, 154).
• High phytoestrogens (isoflavone) that bind to estrogen receptors which increase estradiol (154).
• Reduces total cholesterol, LDL, triglycerides, and improves HDL (152, 153, 154).
• Supports bone health via increased osteoblasts (cells that build bone) activity, reduced bone turnover by inhibiting bone reabsorption, and increased bone mineral density (152, 153, 154).

Selenium

• Supports antioxidant function, cardiovascular health, cognitive function, thyroid health, and immune health (145, 146).
• Combats atherosclerosis, high cholesterol (hypercholesterolemia), and type 1 diabetes (147).
• Supports thyroid health via decreased circulating thyroid autoantibodies in patients with chronic autoimmune thyroiditis (AIT) (146).
• Increases the activity of selenoproteins that decrease reactive oxygen species (inflammation), increases natural killer activity, and increases glutathione (master antioxidant) levels (145, 147).

Slippery Elm Bark Powder

• Supports immune health, antioxidant function, and may combat liver carcinogenesis (276).
• Supports antioxidant function via diphenyl-2-picrylhydrazyl radical scavenging and hydroxyl radical scavenging, and improved macrophage (immune cell) activity (276).
• Combats liver carcinogenesis via y activating the mitochondrial pathway of apoptosis (cell death) of cancer cells (276).

Spirulina

• Supports reduced cholesterol, blood pressure, blood sugar regulation, reduces inflammation, reduced body fat, and supports antioxidant function (301, 302).

Tryptophan

• Decreases anxiety, supports positive mood, supports gut brain axis, and an improved sleep cycle (259,260). 
• Decreases anxiety via increases in 5 HTP (259, 260).
• Improves circadian rhythm via increased natural melatonin production (259,260).
• Supports gut brain axis via natural increased production of serotonin in gut neurons (260). 

Vitamin A (beta carotene)

• Supports vision health, skin health, immune health, and increases antioxidant support (182, 183).
• Supports antioxidant function via decreased inflammatory cytokines (inflammation), decreased reactive oxygen species, and increased L-glutathione production (master antioxidant) (182, 183).
• Supports visual health via increased amounts of plasma vitamin A in macular (eye) tissues (182, 183).

Vitamin B1 (Thiamine)

• Supports aerobic energy metabolism (oxidative phosphorylation), cell growth, optimal neuronal conduction (nerve impulses), and cardiovascular health (94).
• Supports cardiovascular function and aids as a neuroprotective agent in individuals with vitamin B-1 deficiencies (94, 95).

Vitamin B2 (Riboflavin)

• Supports conversion and activation of other B vitamins, red blood cell production and serves as a cofactor for both glucose and fat metabolism (energy production) (92, 93).

Vitamin B3 (Niacin)

• Major B vitamin that supports cardiovascular health by inhibiting hepatic (liver) triglyceride synthesis, reducing very-low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (9).
• Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9).
• Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9).
• Supports healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (9).
• Prevents pathologies (diseases) such as Pellagra and reduces the prevalence of nervous anorexia, cancer, and Crohn's disease (10, 11).

Vitamin B5

• Supports energy production, cell growth, cell repair, cognitive function, increased hippocampal volume (memory), and optimized bioenergetics (burning of carbohydrates, fat, and protein) (96).

Vitamin B6

• Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40).
• Reduces plasma glucose (blood sugar levels) via by inhabiting the activity of small-intestinal a-glucosidases (enzymes associated with glucose metabolism) (39).
• Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38, 40).
• May support blood sugar regulation in women with gestational diabetes (40).
• Cofactor for enzymes involved in DNA metabolism (40).

Vitamin B12

• Supports proper DNA synthesis, folate cycle function, energy production, cognitive function, and immune health (51, 53).
• Aids as an antioxidant via direct scavenging of reactive oxygen species (inflammation), preserving l-glutathione levels (master antioxidant), and reducing oxidative stress (51).
• May prevent vitamin b-12 deficiency diseases such as anemia, neurodegenerative disease, cardiovascular disease, and osteoporosis (53).

Vitamin C

• Supports immune, cardiovascular, skin, cognitive, fat burning, and digestive health (97, 98).
• Supports immune health via increased oxidant, free radical scavenging, and fueling neutrophilic (immune cell) activity in chemotaxis, phagocytosis, and microbial killing (97, 98).
• Supports fat burning by increasing carnitine biosynthesis (molecule required for mitochondrial fatty acid oxidation) (97, 98).
• Supports accelerate bone healing after a fracture, increase type 1 collagen synthesis, and reduce oxidative stress (inflammation) (98).

Vitamin D

• Supports exercise performance, immune health, muscle growth, optimal bone health, hormonal health, immune function, increased sexual health, cardiovascular health, glucose tolerance, strength, and positive mood (77, 78, 79).
• Supports hormonal health via high amounts of vitamin D receptor (VDR) activity in hormone-based negative feedback loop reactions (77, 78).
• Supports cardiovascular health via improved absorption of calcium, reduced atherosclerotic activity, stimulating cardiomyocytes, and improved vascular health (77, 78).
• Supports exercise performance via reduced exercise-associated inflammation and muscle damage (77, 78).
• Supports sexual health via increased activity of Vitamin D receptor activity of testosterone production (79).
• Supports immune function via decreases of inflammatory cytokines and aiding immune cells (77, 78).
• Supports joint health via regulating calcium and phosphorus and bone remodeling along with other calcium-regulating actions (77, 78).

Vitamin E

• Supports immune function, cognitive health, cardiovascular health, and bone health (204, 205, 206, 207, 208).
• Supports immune health via neutralizing free radicals and reactive oxygen species, and increased T lymphocyte-mediated immune function (204).
• Supports cardiovascular health via reduced cholesterol (204).
• Supports cognitive function via reduced oxidative stress, inflammation, and DNA damage of neuronal tissues (208).

Wild Yam Extract

• May support hormonal balance in women via increased progesterone production (151).
• Supports the reduction of atherosclerosis and improved vascular flow (151).

Yohimbine Bark

• May support increased energy, sexual function, and increased metabolism (347).
• May support sexual function via decreased prevalence of erectile dysfunction (347).

Zinc

• Supports immune function, skin health, cognitive function, and vision (172, 173).
• Supports stimulation of the innate and adaptive immune system (172, 173).
• Supports the activation of lymphocytes and activation of innate and T cell-mediated immunity (172, 173).
• Supports cognitive function by modulation of neuronal signaling in areas of the brain associated with memory and learning (hippocampus) (172, 173).

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